Omics Advances in Ecotoxicology

Advances in Epigenetics and Integration of Omics in Lupus

Systemic lupus erythematosus (SLE) is a chronic, multi-organ disease that predominantly affects young women of childbearing age. It is also a disease in which epigenetic modulation is emerging as an important mechanism for understanding how the environment interacts with inherited genes to produce disease. Much of the genetic risk for SLE identified in genome-wide association studies has been s...

21st century Ecotoxicology and Human toxicology: Applications and perspectives for the use of OMICs data

There are currently in the region of 100,000 chemicals in commercial use, making it impossible to monitor and assess the biological effects of exposure to each individual compound, much less mixtures given the finite scientific resources available. Historically, regulatory requirements on chemical risk assessments are largely based upon in vivo toxicity testing of individual substances on "repr...

Ecotoxicology.

Ethics in science: ecotoxicology

Predictive ecotoxicology emphasizes the probable environmental outcome of exposure to toxics, rather than the mere appraisal of existing damage, and in so doing raises some complex but interesting ethical issues. Awareness of endocrine-disrupting chemicals is blurring the line between humankind and other life forms in toxicity testing by providing evidence that both humans and wildlife suffer a...

Transcriptomics in ecotoxicology

The emergence of analytical tools for high-throughput screening of biomolecules has revolutionized the way in which toxicologists explore the impact of chemicals or other stressors on organisms. One of the most developed and routinely applied high-throughput analysis approaches is transcriptomics, also often referred to as gene expression profiling. The transcriptome represents all RNA molecule...